Fentanyl class of drug

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Fentanyl is an opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management. Fentanyl, a potent opioid agonist, was developed in the s to fill a need for strong and rapid analgesia. Label , 15 , 16 , 17 , 18 , 19 , 20 , 21 Fentanyl is related to other opioids like morphine and oxycodone. Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. Fentanyl was FDA approved in Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia.

Label These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Label Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients. Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.

Fentanyl produces strong analgesia through its activation of opioid receptors. Label , 6 It has a duration of action of several hours and a wider therapeutic index as patients develop tolerance to opioids. Label Fentanyl is associated with a risk of addiction and abuse and should not be mixed with alcohol or benzodiazepines. Fentanyl binds to opioid receptors, especially the mu opioid receptor, which are coupled to G-proteins. Fentanyl transmucosal lozenges reach a C max of 0. Fentanyl sublingual spray reached a C max of 0. Fentanyl transdermal systems reached a C max of 0. The oral volume of distribution is Fentanyl crosses the blood brain barrier 9 and the placenta.

Fentanyl is metabolized to a of inactive metabolites. The half life of fentanyl is 7 hours. Total plasma clearance of fentanyl is 0. Fentanyl has an intravenous LD 50 of 2. Symptoms of overdose include respiratory depression, somnolence, stupor, coma, skeletal muscle flaccidity, cold and clammy skin, pupillary constriction, pulmonary edema, bradycardia, hypotension, airway obstruction, atypical snoring, and death.

Label , 15 , 16 , 17 , 18 , 19 , 20 In case of overdose, patients should receive naloxone or nalmefene to reverse the action of the opioids as well as supportive measures to maintain the airway or advanced life support in the case of cardiac arrest.

Mark Rubino, "Process of making fentanyl intermediates. Patent US, issued May 11, Interactions Drug Interactions Food Interactions. Clinical Trials. Spectra Mass Spec Spectra. Targets 4. Enzymes 2. Carriers 2. Transporters 1. Identification Summary Fentanyl is an opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management. Reduce drug development failure rates. See how. Avoid life-threatening adverse drug events. Learn more. This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately.

The absence of an interaction does not necessarily mean no interactions exist. Drug Interaction Integrate drug-drug interactions in your software. Identify potential medication risks. Easily compare up to 40 drugs with our drug interaction checker. Get severity rating, description, and management advice. Our datasets provide approved product information including: dosage, form, labeller, route of administration, and marketing period.

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Pricing information is supplied for informational purposes only. Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. General Function Voltage-gated calcium channel activity Specific Function Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone Exp Neurol. CNS Drugs. Bioorg Med Chem. Epub Jan Epub Jun Nucleic Acids Res.

J Physiol. Epub Apr General Function Opioid receptor activity Specific Function G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers aling via guanine n Braz J Med Biol Res. Wound Repair Regen.

J Cardiothorac Vasc Anesth. Clin Pharmacokinet. Clin Ther. General Function Opioid receptor activity Specific Function G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synt Epub Mar 5.

General Function Xenobiotic-transporting atpase activity Specific Function Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. General Function Vitamin d3 hydroxylase activity Specific Function Cytochromes P are a group of heme-thiolate monooxygenases. It performs a variety of oxidation react J Pharmacol Exp Ther. Role of CYP3A4. Drug Metab Dispos. It oxidizes a variety of structurally un Flockhart Table of Drug Interactions [ Link ].

Its main function is the regulation of the colloid Epub Oct Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in Show full image. A Mu-type opioid receptor.

A Delta-type opioid receptor. U Kappa-type opioid receptor.

Fentanyl class of drug

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Fentanyl Sublingual Spray